抑郁症静息态脑功能异常及其与行为抑制激活的关系.docVIP

抑郁症静息态脑功能异常及其与行为抑制/激活的关系 王晓霞1，蒋成刚2，张 俐1，冯正直1（400038重庆，第三军医大学心理学院：基础心理学教研室1；400042 重庆，第三军医大学大坪医野战外科研究所院神经内科2；400038重庆，第三军医大学心理学院：院长办公室1） [摘要] 目的：通过抑郁症患者静息态功能磁共振成像技术结合比率低频振幅(fractional amplitude of low-frequency fluctuation,fALFF）指标，考察抑郁症患者脑结构和功能变化。方法：选取年龄、性别和文化程度匹配的抑郁症患者10名和正常对照组被试13名，利用fALFF分析抑郁症患者静息状态下脑功能异常特点及其与行为激活/抑制系统的关系。结果：右侧小脑、左侧海马旁回、左额内侧回的fALFF值显著高于对照组，而左侧额中回、右侧额上回和右中央前回的fALFF值显著低于对照组。对照组右侧小脑fALFF值和行为抑制（BIS）分数呈负相关(P=0.009)，左额内侧回fALFF值和行为驱力（BASD）分数呈负相关(P=0.020)。患者组左侧额中回的fALFF值和愉悦追求（BASF）分数呈正相关（P=0.049）。结论：抑郁症患者在默认网络、情感调节环路等多个区域存在自发神经活动能量异常，且与行为抑制/激活功能异常相关。 [关键词] 比率低频振幅；静息态；抑郁症；磁共振成像 Abnormal resting state of MDD: the correlation with behaviral inhibition/ activation Wang Xiaoxia1, Jiang Chenggang2, Zhang Li1, Feng Zhengzhi3 (1Department of Basic Psychology, School of Psychology, 2Department of Clinical Psychology, Daping Hospital, 3School of Psychology, Third Military Medical University, Chongqing, 400038) ［Abstract］ Objective To examine the abnormal resting state functional connectivity in major depression. Methods Ten participants diagnosed with major depression, and thirteen healthy controls matched with age, gender and education were enrolled and scanned with 3.0T MRI scanner. The fALFF index were compared between groups using REST and further correlated with BIS/BAS in spss. Results MDD patients exhibited heightened fALFF in right cerebellum, left parahippacampus, left medial frontal gyrus, and decreased fALFF in left median frontal gyrus, right superior frontal gyrus and right precental gyrus. In controls, fALFF of right cerebellem was negatively correlated with BIS, fALFF of left medial frontal gyrus were negatively correlated with BASD. In MDD, fALFF of left median frontal gyrus was positively correlated with BASF. Conclusions The abnormal fALFF pattern of MDD was identified in default mode network and mood regulation circuit, and correlated with BIS/BAS index. ［Key words］ fractional amplitude of low frequency fluctuation; resting state; major depres