(2006 —— 2007 学年第二学期)药理考题.docVIP

山东大学医学院 （2006 —— 2007 学年第二学期） 2004级 临床医学七年制 药理学期末考试试题（A卷） final ExamNATION of Pharmacology for 7-YMS-2004 题号 一 二 三 四 五 六 七 总分 统分人 得分 得分 评卷人 一、选择题：（A型每题0.5分，X型每题1分, 共 50分） Type A Choice questions (only one answer is correct) 1．A drug with t1/2 3 hours is given intravenously, the steady state of plasma concentration can be expected within A．3 hrs B．8 hrs C．10 hrs D．15 hrs E．20 hrs 2．Which of the following is true for a drug whose elimination from plasma shows first-order kinetics? the half-life of the drug is proportional to the drug concentration in plasma the amount eliminated per unit time is constant the rate of elimination is proportional to the plasma concentration elimination involves a rate-limiting enzyme reaction operating at its maximal velocity a plot of drug concentration versus time is a straight line 3．A drug eliminated with first-order kinetics, the concentration of the drug in plasma is 200mg/L, at 10 o’clock in the morning after administration of a single dose, the drug plasma concentration is 25 mg/L, at 10 o’clock on second day morning, its t1/2 is A．4h B．6h C．12h D．24h E．8h 4. Aspirin is a weak acid with 4.5 of pKa, what percentage of lipid-soluble form will be in the stomach juice with 2.5 of pH? A. 0.99% B. 9% C. 9.09% D. 90.9% E. 99.0% 5. In this graph，drugs A，B and C are analogs，then A. A has a greater potency than B B. A has a greater efficacy than C C. B has less potency than C D. A has a greater potency than C E. B has a greater efficacy than C 6. Which of the following statements is correct? A. if 10mg of drug A produces the same response as 100mg of drug B, drug A is more efficacious than drug B. B. the greater the efficacy, the greater the potency of a drug C. in selecting a drug, potency is usually more important than efficacy D. a competitive antagonist increases ED50 E. variation in response to a drug among different individuals is most likely to occur with a drug showing a large therapeutic index 7. Amon