p53基因突变和p16基因缺失与肝癌的相关性.docVIP

p53基因突变和p16基因缺失与肝癌的相关性 【关键词】 ,基因,p53；基因,p16；癌,肝细胞 Correlation of p53 gene mutation and p16 gene deletion with hepatocellular carcinoma 【Abstract】AIM: To detect the probability of p53 gene mutation and p16 gene deletion in the plasma of the patients with hepatocellular carcinoma and to explore its correlation with onset and development of HCC and its clinical significance. METHODS: PCR was used to amplify p53 gene exon 58 and the immunohistochemistry was employed to determine the deletion of p16 gene. The difference between the pa