胰岛素样生长因子―1与原发性高血压及左心室肥厚的关系.docVIP

胰岛素样生长因子―1与原发性高血压及左心室肥厚的关系 　　[摘要] 目的 观察原发性高血压（EH）患者血清胰岛素样生长因子-1（IGF-1）水平及其与原发性高血压及左心室肥厚（LVH）的关系。 方法 选择原发性高血压患者132例为观察组，其中高血压1级（EH1级）42例，高血压2级（EH2级）46例，高血压3级（EH3级）44例，单纯EH无LVH（EH-非LVH组）68例，EH合并LVH（EH-LVH组）64例。采用放射免疫法测定原发性高血压各组患者和健康体检者（正常对照组）60例的血清IGF-1水平及左心室质量指数，并对比分析。 结果 血清IGF-1水平，观察组[（296.41±60.51）ng/mL]明显高于对照组[（172.41±41.25）ng/mL]，差异有统计学意义（P 0.05），EH1级、EH2级和EH3级组患者与对照组比较，差异均有高度统计学意义（P 0.01）。EH-LVH组、EH-非LVH组与对照组比较，血清IGF-1水平、左心室质量指数均明显较高，差异均有统计学意义（P 0.05），且EH-LVH组均高于EH-非LVH组（P 0.05）。IGF-1水平与左心室质量指数呈正相关（r = 0.42，P 0.05）。 结论 EH患者血清IGF-1水平明显升高，IGF-1可能参与了EH的发生、发展过程。 　　[关键词] 原发性高血压；胰岛素样生长因子-1；左心室肥厚 　　[中图分类号] R541.3 [文献标识码] C [文章编号] 1673-7210（2014）02（c）-0152-03 　　Relationship of insulin-like growth factor 1 with essential hypertension and left ventricular hypertrophy 　　QIAN Jiahua1 GAO He2 　　1.Department of Internal Medicine， Maternal and Child Health Care of Tongxiang City， Zhejiang Province， Tongxiang 314500， China； 2.Department of Internal Medicine， Chinese Medicine Hospital of Tongxiang City， Zhejiang Province， Tongxiang 314500， China 　　[Abstract] Objective To observe the serum insulin-like growth factor 1 （IGF-1） level of essential hypertension （EH） patients and the relationship of IGF-1 with EH and left ventricular hypertrophy （LVH）. Methods A total of 132 EH patients were selected as observation group， there were 42 cases of EH1， 46 cases of EH2， 44 cases of EH3， 68 cases of EH without LVH （EH non-LVH group）， 64 cases of EH with LVH （EH-LVH group）. Levels of serum IGF-1 of each group of EH patients and 60 cases of healthy physical examination （normal control group） were tested by radiation immune method， and comparatively analyzed. Results The levels of serum IGF-1 in observation group was （296.41±60.51） ng/mL， significantly higher than the control group （172.41±41.25） ng/mL， the difference was statistically significant （P 　　[Key words] Essential hypertension； Insulin-like growth factor 1； Left ventricular hypertrophy 　　原发性高血压（essential hypertensi