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RapidInformationonOLMNo216140430RapidInformationonOLMNo216140430
Rapid Information on Olmesartan and other ARBs
No.216
2014/04/30
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(Toru Komai, Ph.D.)
216-1: The findings from acute myocardial infarction (AMI) model mice suggests that earlier administration of olmesartran in patients with AMI is a potential preventive approach for cardiac rupture.
Title:Olmesartan prevents cardiac rupture in mice with myocardial infarction by modulating growth differentiation factor 15 and P53. 2-3
216-2: In patients with moderate-to-severe hypertension, long-term treatment with OLM/AML/HCTZ triple combination therapy was well tolerated and effective.
Title:Open-Label Study Assessing the Long-term Efficacy and Safety of Triple Olmesartan/Amlodipine/Hydrochlorothiazide Combination Therapy for Hypertension. 4
216-3:Patients treated with ACEI had significantly lower long-term mortality compared with those treated with ARB from 2 to 5 years after AMI.
Title:Comparison of 5-Year Survival After Acute Myocardial Infarction Using Angiotensin Converting Enzyme Inhibitor versus Angiotensin II Receptor Blocker 5
Abbreviations:
BP: blood pressure, SBP/DBP: systolic/ diastolic BP, RAS: renin–angiotensin system,
Ang II: angiotensin II, ARB: angiotensin II receptor blocker,
CCB: calcium channel blocker, ACE-I: angiotensin converting enzyme inhibitor,
OLM: olmesartan, AML: amlodipine, HCTZ: hydrochlorothiazide, CVD: cardiovascular disease, CHF: chronic heart failure, CKD: chronic kidney disease,
216-1: The findings from acute myocardial infarction (AMI) model mice suggests that earlier administration of olmesartran in patients with AMI is a potential preventive approach for cardiac rupture.
Cardiac rupture is a catastrophic complication for patients with acute myocardial infarction (MI). The incidence of cardiac rupture is 1 – 6% a
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