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RapidInformationonOLMNo.171130114RapidInformationonOLMNo.171130114
Rapid Information on Olmesartan and other ARBs
No.171
2013/01/14
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(Toru Komai, Ph.D.)
171-1:Switching from failed monotherapy to a treatment regimen based on AML/OLM±HCTZ was well improved the achievement of BP goals in patients with hypertension, irrespective of diabetic status or presence of metabolic syndrome.
Title:Efficacy of an amlodipine/olmesartan treatment algorithm in patients with or without type 2 diabetes and hypertension (a secondary analysis of the BP-CRUSH study). 2-3
171-2:Adding HCTZ to a range of OLM/AML dose combinations improved BP control by significantly lowering DBP and SBP and significantly increasing BP threshold achievement in patients with moderate-to-severe hypertension.
Title:Efficacy and safety of triple antihypertensive therapy with the olmesartan/amlodipine/hydrochlorothiazide combination. 3
171-3:In Japanese elderly high-risk hypertensive patients, olmesartan plus CCB combination therapy was more effective in prevention of cardiovascular events in patients with CKD compared with high-dose olmesartan therapy. (A subgroup analysis of the OSCAR study)
Title:An angiotensin II receptor blocker-calcium channel blocker combination prevents cardiovascular events in elderly high-risk hypertensive patients with chronic kidney disease better than high-dose angiotensin II receptor blockade alone. 4-5
Abbreviations:
BP: blood pressure, SBP: systolic BP, DBP: diastolic BP
CVD: cardiovascular disease, CHF: chronic heart failure, CKD: chronic kidney disease, T2DM: type 2 diabetes mellitus, BNP: brain natriuretic peptide,
OLM: olmesartan, AML: amlodipine, HCTZ: hydrochlorothiazide, CCB: calcium channel blocker, HR: hazard ratio, OR: odds ratio,
171-1:Switching from failed monotherapy to a treatment regimen based on AML/OLM±HCTZ was well impro
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