[深低温冻存脐血复温后输注不良反应发生及其影响因素分析.docVIP

深低温冻存脐血复温后输注导致高血压的影响因素分析 黄璐 宋瑰琦 吴云 作者单位：230601合肥 安徽医科大学护理学院，安徽医科大学附属省立医院血液科 通信作者：宋瑰琦，Email：songguiqi66@ 基金项目：安徽省2012年度第二批科技计划项目（12010402120） 【摘要】：目的：探讨深低温冻存脐血复温后输注发生高血压的情况及其影响因素。方法：选择2000-2011年我院进行单份非血缘脐血移植（UCBT）治疗血液病的116例患者，移植当天由中心静脉输注 -196度液氮中冻存经37-42度水浴箱复温后的脐血，持续监测患者的血压变化。结果：116例单份UCBT患者中78例（67.2%）出现了不同程度的高血压，通过及时有效的护理，78例脐血干细胞输注均顺利完成。通过单因素分析发现输注时间短、单位时间输入体内每毫升有核细胞数（TNC）高的患者，其高血压的发生率高，差异具有统计学意义（p=0.000，p=0.023）。结论：深低温冻存脐血输注发生高血压的频率高，但加强脐血输注时的血压监测和护理可以保证脐血输注的安全性。输注时间和单位时间输入病人体内每毫升的有核细胞数是高血压发生的危险因素。 【关键词】：深低温冻存 脐血 高血压 Influencing factors of cryopreserved cord blood cell infusion-related hypertension Huang Lu, Song Gui-qi, Wu Yun 【Abstract】: Objective: To explore the cryopreserved cord blood (CB) infusion-related hypertension and analyze the cause of it.Methods:Investigate 116 hematological malignancies patients,who undergoing single unrelated CB transplantion from 2000 to 2011.CB units were cryopreserved in -196℃ liquid nitrogen, thawed in a water bath at 37-42℃ and infused through a central intravenous catheter, blood pressure were monitored continuously in the infusion and after.Results: 116 cases of CB transplant patients, 78 cases (67.2%) experienced varying degrees of hypertension, but through a timely and effective care, all the 78 cases of CB infusion were successfully completed. Univariate analysis indicated that shorter infusion time and higher total nucleated cell (TNC) infused to patients per minute were found to be higher incidence of hypertension (p=0.000,p=0.023).Conclusion: The incidence of cryopreserved CB infusion-related hypertension is high, but strengthen the blood pressure monitoring and care,can ensure the safety of cord blood transfusion .The infusion time and per minute TNC are factors contribute to hypertension. 【Keywords】: cryopreserved umbilical cord blood hypertension 脐血已作为造血干细胞的一个重要来源应用于非血缘异基因移植，目前，脐血移植（Umbilical cord blood transplantation, UCBT）是治疗白血病等恶性肿瘤和非恶性难治性疾病最为有效的方法之一[1]。脐血为实物冻存在-196℃液氮中，移植时需要快速复温、及时回输给患者，但在输注解冻