蛋白尿的发生机制__培训课件.pptVIP

足细胞结构的完整对于维护裂孔隔膜和足细胞－基质之间的连接的稳定性非常关键。保持滤过裂孔的开放和足细胞与毛细血管之间的黏附，足突内形成一些专门的细胞骨架。其主要的功能就是维系这些裂孔膜 多蛋白复合物和毛细血管基底膜之间的黏附； 肾小球的滤过是一个动态的过程，需要机械力和滤过膜的通透性。足细胞内的细胞骨架保证了足细胞的收缩以适应滤过时的毛细血管扩张。 F-actin Forms the Structural Support in Podocyte Foot Processes Microfilaments are the predominant cytoskeletal constituent of the foot process. The individual subunits of actin are known as globular actin (G-actin), whereas the filamentous polymer composed of G-actin subunits (a microfilament), is called F-actin. The microfilaments are the thinnest component of the cytoskeleton, measuring 7 nm in diameter. Similar to mi