ppt课件-experimental error correctionof bio macromolecular crystal（实验误差correctionof生物大分子晶体）.pptVIP

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ppt课件-experimental error correctionof bio macromolecular crystal（实验误差correctionof生物大分子晶体）.ppt

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9/5/2003 Automatic Structure Determination--- given a data set, solve the structure quickly and better, by using a parallel workflow engine to automatically and systematically search algorithm/program and parameter space Zheng-Qing (Albert) Fu SER-CAT, APS, Argonne National Laboratory Biochem. Mol. Biology, Univ. Of Georgia, Athens, Georgia What we learnt from Structural Genomics 1). How to detect and avoid these problems before too late? In addition to the unexpected problems, there are many other issues during data collection: A New Statistic Index, Ras, to More Objectively and Accurately Evaluate Signal/Noise Ratio Signal-based Data Collectionwith Ras as a reliable indicator, diffraction data can be acquired more appropriately for a given crystal, by monitoring the Signal/Noise ratio through the data collection After data processed, we have to face a set of different issues in the structure-solving process AcknowledgmentGeorge Wu and many Ph.D. students including Dongsheng Che, Jizhen Zhao, Feng Sun, Haijin Yan, Dept. of Computer Sciences, UGAB.C. Wang, John Rose, SER-CAT, SECSG, UGAJohn Chrzas, Zhongmin Jin, Jim Fait, SER-CAT, APSAndy Howard, Illinois Institute of TechnologyRobert Sparks, Bruker (formerly Siemens) AXS Inc.Xuong Nguyen-Huu, UC San DiegoGeorge Sheldrick, University of G?ttingen, Germany.Randy Read, Cambridge University, EnglandTom Terwilliger, Los Alamos National Lab Peter Briggs (CCP4, England) and Authors of all the programs plugged into SGXPro.Work is supported in part with funds from the National Institute of Health (GM62407) and SERCAT, APS * * 2007 ACA Summer School Cloned (7%) Crystals (33%) StructuresOverall Success Rate (from Clone to Structure): 2.45% All Targets Cloned Crystals Structures Gene Crystallization Phasing Key to Success From gene to final structure, crystallographic analysis of protein structures is a complicated Multi-Step, Multi-Discipline, Costly, and Systematic Engineering Project. Data Collectio