ppt课件-how humans use marine organisms secondary metabolites（人类利用海洋生物的次级代谢物如何）.pptVIP

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2017-01-25 发布于四川
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ppt课件-how humans use marine organisms secondary metabolites（人类利用海洋生物的次级代谢物如何）.ppt

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Bill Gerwick, OSU What are Secondary Metabolites? Also known as natural products, secondary metabolites are organic compounds (small molecules) that are not significant in the everyday processes, development or normal growth of an organism. However, they play an important role in the ecology of the organism such as defense, or facilitating reproduction, among others. For centuries, humans have used plants secondary metabolites as defense and valuable medical resources, however, during the last 40 years marine natural products have been the center of numerous research projects Marine Secondary Metabolites A large number of antibiotics, medical, and industrial products are produced from secondary metabolites. Although plants natural products are very rich, marine invertebrates such as sponges, bryozoans, mollusks, tunicates, etc, contribute greatly to the production of marine secondary metabolites (from symbiotic bacteria or fungi), producing the largest chemical diversity of natural products. Use of Marine Secondary Metabolites Porifera (sponges) - Bryozoa (bryozoans)? Produce cytotoxic compounds– A potential anti-cancer drug Cytarabine Isolation of C-nucleosides from the Caribbean sponge, Cryptotheca crypta. This discovery provided the basis for the synthesis of cytarabine, the first marine-derived anticancer agent to be developed for clinical use. Ecteinascidin 743 Natural marine product isolated from the Caribbean tunicate Ecteinascidia turbinata Potential new anti-cancer compound Bryostatin Compound derived from Bugula neritina. Many medicinal potentials: Anti-tumor Preservation of memory- Alzheimer Depression Not only marine macroorganisms play an important role in the production of natural products, microorganisms also are important, being unexploited resources for novel bioactive compounds Use of secondary metabolites produced by marine fungi , metabolic pathways, and origin Antitumors Antibacterials Alcyonarian (bacterial)? Mollusks (us