Enteric Bacteria Mississippi University for Women肠道细菌密西西比女子大学.pptVIP

Enteric Bacteria Bacteria that cause diarrhea and dysentery Enteric Bacteria Enteric bacteria: secretory or watery diarrhea Vibrio cholerae ETECs (Enterotoxigenic E. coli) EPECs (Enteropathogenic E. coli) Invasive/Tissue Damaging Enteric pathogens: Bloody diarrhea and dysentery EIECs (Enteroinvasive E. coli) Shigella spp Salmonella spp EHECs (Enterohemmorhagic E. coli) Slow bacterial Infection Pathogens Helicobacter pylori What are enteric bacteria? Functional definition: Gram negative facultatively anaerobic rods Coliforms: enteric bacteria that ferment lactose to produce acid and gas What do gram negative bacteria look like? Lipopolysaccharide Cytoplasmic membrane Pili Outer membrane Flagella Periplasm Enteric Bacteria Enteric bacteria: secretory or watery diarrhea Vibrio cholerae ETECs (Enterotoxigenic E. coli) EPECs (Enteropathogenic E. coli) Comes from raw shellfish: These organisms (especially Vibrio) normally found in coastal regions Are consumed by small crustaceans and larger filter feeders Bacteria increase in number during conditions that produce algal bloom growth (seasonal or pollution) Enteric Bacteria Invasive/Tissue Damaging Enteric pathogens: Bloody diarrhea and dysentery EIECs (Enteroinvasive E. coli) Shigella spp (produces Shiga toxin) Salmonella spp-- found in undercooked chicken eggs and dairy products EHECs (Enterohemmorhagic E. coli)—found in undercooked hamburger etc produces Shiga toxin Example:: E. coli O157:H7 Enteric Bacteria Slow bacterial Infection Pathogens Helicobacter pylori Causes gastric and duodenal ulcers ulcers are caused by localized non-specific immune response and by the fact that the bacteria produce cytotoxins Causes cancer Found associated with the pyloric region of the stomach where it colonizes stomach for decades and causes a persistant low grade inflammation of the stomach Helicobacter pylori—why doesn’t it get killed by stomach acids? H. pylori goes to region of stoma