木丹颗粒联用弥可保治疗糖尿病性周围神经病变的临床观察.docVIP

木丹颗粒联用弥可保治疗糖尿病性周围神经病变的临床观察 　　doi：10.3969/j.issn.1007-614x.2014.20.60 　　摘 要 目的：观察木丹颗粒治疗糖尿病周围神经病变（DPN）的临床疗效。方法：DPN患者164例，随机分为治疗组A，治疗组B和对照组。3组均给予基础治疗。治疗组A服木丹颗粒7 g/次，3次/日；治疗组B服木丹颗粒7 g/次，3次/日，弥可保0.5 mg/次，3次/日；对照组只服弥可保0.5 mg/次，3次/日。3组均治疗8周。结果：治疗组A、治疗组B与对照组比较，P0.05，差异有统计学意义。治疗组B与组A比较，P0.05，差异有统计学意义。结论：木丹颗粒联合弥可保治疗DPN临床效果显著，安全有效。 　　关键词 木丹颗粒 糖尿病周围神经病变 弥可保 　　Clinical observation of Mu Dan granule combined with mecobalamin in the treatment of diabetic peripheral neuropathy 　　Lin Jihong 　　Department of Gastroenterology，the First Peoples Hospital of Kaifeng County，Henan 475100 　　Abstract Objective：To observe the clinical effect of Mu Dan granule in the treatment of diabetic peripheral neuropathy（DPN）.Methods：164 cases of DPN were randomly divided into the treatment group A，the treatment group B and the control group.The three groups were given basic treatment.The treatment group A were given Mu Dan granule 7 g one time，3 times one day.The treatment group B were given Mu Dan granule 7 g one time，3 times one day，mecobalamin 0.5 mg one time，3 times one day.The control group only were given mecobalamin 0.5 mg one time，3 times one day.3 groups were treated for 8 weeks.Results：The treatment group A，the treatment group B were compared with the control group， and there was significant difference（P0.05）.The treatment group B was compared with the group A， and there was significant difference（P0.05）.Conclusion：Mu Dan granule combined with mecobalamin in the treatment of DPN has significant clinical effect，and it is safe and effective. 　　Key words Mu Dan granule；Diabetic peripheral neuropathy；Mecobalamin糖尿病神经病变（DPN）是糖尿病的常见慢性并发症之一，其发生率40%～60%，其机制目前还不完全清楚，临床上对此尚缺乏特异性治疗方法。木丹颗粒是治疗DPN的6类新药，由黄芪、三七、延胡索、赤芍、丹参等9味中药组成，具有益气养血、通络止痛、活血祛瘀的作用。作者选用木丹颗粒联用弥可保对DPN进行比较治疗，现报告如下。 　　资料与方法 　　2010年2月-2011年12月收治DPN患者181例，随机分为3组，其中治疗组A 70例，男42例，女28例，年龄（54.5±10.5）岁，病程5个月～26年，平均（10.5±5.0）年；治疗组B 65例，男40例，女25例，年龄（53.5±10.5）岁，病程6个月～27年，平均（10.5±5.5）年；对照组56例，男36例，女20例，年龄（55.0±9.5）岁，病程4个月～25年，平均（10.0±5.5）年。性别、年