Prognostic Implications of Left Ventricular Mass and Geometry左心室质量和几何形状对预后的影响.pptVIP

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Prognostic Implications of Left Ventricular Mass and Geometry左心室质量和几何形状对预后的影响.ppt

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Prognostic Implications of Left Ventricular Mass and Geometry左心室质量和几何形状对预后的影响

Prognostic Implications of Left Ventricular Mass and Geometry Following Myocardial Infarction: the VALsartan In Acute myocardial iNfarcTion (VALIANT) Echocardiographic Study Prognostic Implications of Left Ventricular Mass and Geometry Following Myocardial Infarction: the VALsartan In Acute myocardial iNfarcTion (VALIANT) Echocardiographic Study Anil Verma, MD, Jalal Ghali, MD, Alessandra Meris, MD, J. Malcolm O. Arnold, MD, Mikhail Bourgoun, MD, Eric Velazquez, MD, Lars Kober, MD, Marc A. Pfeffer, MD, PhD, Scott D. Solomon, MD Brigham and Women’s Hospital, Wayne State University, University Hospital, LHSC, Duke Clinical Research Institute, Duke University Medical Center, Rigshospitalet, University of Copenhagen BACKGROUND Left ventricular hypertrophy (LVH) and alterations in LV geometry have been associated with increased mortality and other cardiovascular (CV) events Patients with concentric LVH (increased relative wall thickness [RWT] and LV mass index [LVMi]), have been shown to have the highest incidence of adverse CV events, including death There are limited data on the association of LV mass and geometry to prognosis in high risk individuals following myocardial infarction OBJECTIVE To explore the prognostic value of echocardiographically determined LV mass and geometry in the specific setting of high risk MI METHODS METHODS The ASE-recommended formula for estimation of LV mass from 2D linear LV measurements LV mass = 0.8 x {1.04[(LVIDd + PWTd + SWTd)3 - (LVIDd)3]} + 0.6 g LV mass was indexed to body surface area RWT = 2 x PWTd/LVIDd Distribution of Baseline LV-Mass index in VALIANT Baseline characteristics stratified by LV Geometry Baseline Echo Characteristics Stratified by LV Geometry Unadjusted Kaplan Meier Curves for All Cause Mortality Unadjusted Kaplan Meier Curves for Cardiovascular Composite Crude incidence rates/100-person years of adverse CV outcomes stratified by LV geometric patterns LIMITATIONS 2D Echo is limited i