子宫内膜异位症患者体外受精或卵胞浆内单精子注射临床结局与体质量指数的相关性分析.docVIP

子宫内膜异位症患者体外受精或卵胞浆内单精子注射临床结局与体质量指数的相关性分析 　　【摘要】目的：探讨EMS患者IVF或ICSI周期中的体质量指数与其临床结局相关性。方法：回顾性分析我院2011年4月至2013年1月收治的241例采用ICSI或IVF治疗患者的临床资料，将其中的EMS患者按严重程度分为轻度组（n=53）和中重度组（n=46），其余患者设为对照组（n=132）。比较各组Gn用量、hCG日E2水平、Gn天数、移植胚胎数、获卵数、患者体质量指数及临床结局。结果：中重度组患者的Gn用量显著高于轻度组和对照组，而移植胚胎数、获卵数和hCG日E2水平低于轻度组和对照组，差异有统计学意义（P0.05），但轻度组早期自然流产率高于对照组，差异有统计学意义（P0.05）。中重度组患者BMI和临床妊娠率均低于对照组和轻度组，早期自然流产率高于轻度组和对照组，差异有统计学意义（P0.05）。EMS患者BMI指数下降后早期自然流产率增高，两者呈负相关性（r=-0.713，P=0.008）。而与临床妊娠率呈正相关性，临床妊娠率随BMI降低而降低（r=0.695，P=0.012）。结论：EMS患者病情加重后BMI降低，同时自然流产率增高，导致临床结局恶化。 　　【关键词】子宫内膜异位症；身体质量指数；体外受精；卵胞浆内单精子注射 　　Correlation between body mass index and outcome of in vitro fertilization and embryo transfer cycle in patients with endometriosisZHOU Baofeng1， LIANG Jianghong2， DENG Jianping2△. 1. Department of Obstetrics， Shiyan City Maternal and Child Health Care Hospital， Shiyan 442000， Hubei， China； 2. Department of Obstetrics and Gynecology， Shiyan City Taihe Hospital， Shiyan 442008， Hubei， China 　　【Abstract】Objectives： To evaluate the correlation between body mass index and outcome of in vitro fertilization and embryo transfer cycle in patients with endometriosis. Methods： The clinical data of 241 patients from April 2011 to February 2013 were analyzed retrospectively， and EMS patients were divided into mild group （n=53） and moderate-severe group （n=46） and control group （n=132）. Dose of gonadotropin， days of stimulation， BMI， number of oocytes retrieved and embryos transferred with the outcome of IVF were compared. Results： The dose of gonadotropin of moderate-severe group was higher than the control group and mild group， while the day of HCG， number of oocytes retrieved， number of embroies transfered were lower than the other groups （P0.05）， but the early spontaneous abortion rate of mild group was lower than control group （P0.05）. The clinical pregnancy rate and BMI of moderate-severe group were lower than control group and mild group， while the early spontaneous abortion rate was higher （P0.05）. There w