猪苓汤与小蓟饮子治疗湿热型IgA肾病的临床效果.docVIP

猪苓汤与小蓟饮子治疗湿热型IgA肾病的临床效果 　　[摘要] 目的 探讨猪苓汤联合小蓟饮子治疗湿热型IgA肾病的临床效果。 方法 分析2010年2月～2015年2月山东省东营市人民医院肾内科收治的120例湿热型IgA肾病患者的临床资料，依据治疗措施不同分为两组，对照组60例给予强的松基础治疗，观察组60例给予基础治疗+猪苓汤+小蓟饮子联合治疗。观察两组治疗前后24 h尿蛋白定量、内生肌酐清除率（Ccr）、尿素氮（BUN）、肌酐（SCr）、α1-微球蛋白（α1-MG）、视黄醇结合蛋白（RBP）、β2-微球蛋白（β2-MG）情况，比较两组疗效。 结果 两组治疗前24 h尿蛋白定量、Ccr、BUN、SCr比较差异均无统计学意义（P 0.05）。两组治疗后24 h尿蛋白定量均显著低于治疗前（P 0.05）。观察组治疗后24 h尿蛋白定量显著低于对照组（P 0.05）。两组治疗前α1-MG、RBP、β2-MG比较差异均无统计学意义（P 0.05），两组治疗后α1-MG、RBP、β2-MG均显著低于治疗前（P 0.05），且观察组治疗后α1-MG、RBP、β2-MG均显著低于对照组（P 0.05）。观察组总有效率（100%）显著高于对照组（85%），差异有统计学意义（P 0.05）。 结论 猪苓汤联合小蓟饮子治疗湿热型IgA肾病临床效果良好，肾功能恢复明显，值得临床推广应用。 　　[关键词] 猪苓汤；小蓟饮子；湿热型IgA肾病 　　[中图分类号] R692.3 [文献标识码] A [文章编号] 1673-7210（2016）04（a）-0104-04 　　[Abstract] Objective To investigate the clinical effect of Zhuling Decoction combined with Xiaoji Drink in the treatment of damp-heat type of IgA nephropathy. Methods The clinical data of 120 cases with damp-heat type IgA nephropathy admitted to Department of Nephrology of Dongying Peoples Hospital from February 2010 to February 2015 was analyzed， the patients were divided into two groups by different treating methods， 60 cases of control group were given basic treatment of Prednisone， 60 cases of observation group were given basic treatment+Zhuling Decoction + Xiaoji Drink. The conditions of 24 h urine protein quantitation， endogenous creatinine clearance rate （Ccr）， blood urea nitrogen （BUN）， creatinine （SCr）， α1-microglobulin （α1-MG）， retinol binding protein （RBP）， β2-microglobulin （β2-MG） of two groups before and after treatment were observed， the curative effects of the two groups were compared. Results The levels of 24 h urine protein quantitation， Ccr， BUN， SCr of the two groups before treatment had no statistically significant differences （P 0.05）， the levels of 24 h urine protein quantitation of the two groups after treatment were lower than those before treatment， the differences were all statistically significant （P 0.05）， the level of 24 h urine protein quantitation i