纤维蛋白原、血小板计数水平在非小细胞肺癌中的临床意义.docVIP

纤维蛋白原、血小板计数水平在非小细胞肺癌中的临床意义 　　[摘要] 目的 研究非小细胞肺癌患者血中纤维蛋白原和血小板计数水平的变化及其临床意义。 方法 整群收集该院2012年1月―2013年6月原发性非小细胞肺癌、肺良性疾病及健康体检者病例共计73例，其中原发性非小细胞肺癌完全切除患者34例、肺良性疾病14例及健康体检者25例进行对照，结合临床资料，回顾分析3组对象纤维蛋白原及血小板计数水平。结果 肺癌组血浆纤维蛋白原和血小板计数高于对照组，纤维蛋白原水平在鳞癌中升高明显，血小板计数在腺鳞癌中升高明显，肺癌组血浆纤维蛋白原和血小板计数与肿瘤分期无明显关系。 结论 纤维蛋白原和血小板水平对非小细胞肺癌的早期诊断具有一定意义。 　　[关键词] 非小细胞肺癌；纤维蛋白原；血小板计数；临床意义 　　[中图分类号] R734.2 [文献标识码] A [文章编号] 1674-0742（2015）12（a）-0065-03 　　[Abstract] Objective To explore the variations of the levels of fibrinogen and platelet count in patients with non-small cell lung cancer and their clinical significance. Methods A total of 73 persons including 34 cases with complete resection of primary non-small cell lung cancer， 14 cases with benign lung disease and 25 healthy controls with health examination admitted in our hospital from January 2012 to June 2013 were selected. The levels of fibrinogen and platelet count in the three groups were analyzed retrospectively combined with the clinical data of them. Results The levels of fibrinogen and platelet count of the lung cancer group were significantly higher than those of the normal controls. The level of fibrinogen in squamous carcinoma was significantly higher than that in other pathology types. The level of platelet count in adenosquamous carcinoma was significantly higher than that in other pathology types. The plasma levels of fibrinogen and platelet count in patients with non-small cell lung cancer had no significant relation with the neoplasm stages. Conclusion Monitoring the levels of fibrinogen and platelet count is instrumental for the early diagnosis of non-small cell lung cancer. 　　[Key words] Non-small cell lung cancer； Fibrinogen； Platelet count； Clinical significance 　　非小细胞肺癌在肺癌患者总数中约占80%～85%[1]，近年来，虽然恶性肿瘤诊治技术发展进步较大，不过由于受到较多不良因素影响，如早期诊断技术不足等，该疾病5年生存率仍旧未得到明显改善[2]。纤维蛋白原、血小板计数水平是极为重要的凝血指标，据相关资料显示，血浆纤维蛋白的表达与恶性肿瘤发生呈正相关，血小板增多往往提示着患者已患上恶性肿瘤及其进展，包括如妇科肿瘤、肺癌及胃癌等[3-4]。由于恶性肿瘤患者常伴有纤维蛋白原、血小板计数水平的升高，故探讨纤维蛋白原与血小板计数联合检测对非小细胞肺癌患者的临床意义[5]。该研究共收集该院2