评价艾司西酞普兰治疗帕金森合并抑郁患者的临床疗效及安全性.docVIP

评价艾司西酞普兰治疗帕金森合并抑郁患者的临床疗效及安全性 　　[摘要] 目的 探讨对帕金森合并抑郁患者采用艾司西酞普兰治疗的疗效及安全性。方法 该次研究对象来源方便选取该院2014年6月―2016年6月收治的帕金森合并抑郁患者120例，依据治疗药物分组，其中对照组（n=60）采用阿米替林治疗，观察组（n=60）采用艾司西酞普兰治疗，比较两组临床疗效及治疗前后HAMA（汉密尔顿焦虑量表）、HAMD（汉密尔顿抑郁量表）、TESS（药物不良反应量表）评分。 结果 观察组临床疗效为93.3%，高于对照组80.0%，对比差异有统计学意义（P0.05），治疗后观察组HAMA评分为（5.2±1.0）分，HAMD评分为（5.5±1.2）分，均明显低于对照组，对比差异有统计学意义（P0.05）；且两组治疗后HAMA、HAMD评分均明显低于治疗前，对比差异有统计学意义（P0.05）；观察组第1周TESS评分为（9.5±1.6）分，第6周为（5.2±1.1）分，均明显低于对照组，对比差异有统计学意义（P0.05）。 结论 艾司西酞普兰治疗帕金森合并抑郁患者临床疗效优良，且安全性高，值得推广。 　　[关键词] 艾司西酞普兰；帕金森；抑郁；疗效；安全性 　　[中图分类号] R5 [文献标识码] A [文章编号] 1674-0742（2016）10（c）-0103-03 　　[Abstract] Objective To explore the use in patients with Parkinsons merge depression escitalopram citalopram efficacy and safety of treatment.Methods Object of this study comes from Convenient selection our hospital from June 2014 to June 2016 treated 120 cases of patients with Parkinson merge depression， according to the treatment group， the control group （n = 60） with amitriptyline treatment， observation group （n = 60） with escitalopram citalopram treatment， compared two groups of clinical curative effect and treatment before and after the HAMA （Hamilton anxiety scale）， HAMD （Hamilton depression rating scale）， TESS （adverse drug reaction scale） score. Results The clinical curative effect of observation group was 93.3%， 80.0% higher than the control group， compared significant difference （P 0.05）， the observation group after treatment （5.2±1.0）points for HAMA score points， HAMD score of （5.5±1.2） points， were significantly lower than the control group， compared significant difference （P 0.05）； And the two groups after treatment of HAMA and HAMD scores were significantly lower than before the treatment， compared significant difference（P 0.05）； Observation group（9.5±1.6）points for week 1 TESS score points， 6 weeks is （5.2±1.1） points， were significantly lower than the control group， compared significant difference （P 0.05）. Conclusion Escitalopram citalopram treatment of Parkinsons d