Bone tissue engineering using 3D 打印组织工程骨.pdf

Materials Today  Volume 16, Number 12 December 2013 RESEARCH Bone tissue engineering using 3D printing R E S E A R C H : R eviewSusmita Bose*, Sahar Vahabzadeh and Amit Bandyopadhyay W. M. Keck Biomedical Materials Research Lab, School of Mechanical and Materials Engineering, Washington State University, Pullman, WA 99164, USAWith the advent of additive manufacturing technologies in the mid 1980s, many applications benefited from the faster processing of products without the need for specific tooling or dies. However, the application of such techniques in the area of biomedical devices has been slow due to the stringent performance criteria and concerns related to reproducibility and part quality, when new technologies are in their infancy. However, the use of additive manufacturing technologies in bone tissue engineering has been growing in recent years. Among the different technology options, three dimensional printing (3DP) is becoming popular due to the ability to directly print porous scaffolds with designed shape, controlled chemistry and interconnected porosity. Some of these inorganic scaffolds are biodegradable and have proven ideal for bone tissue engineering, sometimes even with site specific growth factor/drug delivery abilities. This review article focuses on recent advances in 3D printed bone tissue engineering scaffolds along with current challenges and future directions.Introduction Osseous tissue, known as bone, is made of two different structures; cancellous and cortical bone. Cancellous, or the inner part of bone, is spongy in nature having 50–90 vol% porosity. However, cortical bone is the dense outer layer of bone with less than 10 vol% porosity. Both types of bone undergo dynamic remodeling, matura- tion, differentiation, and resorption that are controlled via interac- tions among osteocyte, osteoblast, and osteoclast cells [1]. Osteoblasts are primarily responsible for new bone formation while osteoclasts are responsible for the resorption o