生物化学中文班课件chapter 22-27 carbonhydrate metabolism-2.pptVIP

第三章 糖的有氧氧化过程;糖的有氧氧化与酵解过程的关系;The citric acid cycle was confirmed to be universal in cells Details worked out by studying highly purified enzymes of the cycle in vitro; Also by isotope tracer experiments in vivo; The cycle is sometimes called the Krebs cycle.;;The TCA cycle provides a chemically feasible way of cleaving a two-carbon compound. Stage 1: Acetyl-CoA production Stage 2: Acetyl-CoA oxidation Stage 3: Electron transfer and oxidative phosphorylation;3.2.1 丙酮酸脱羧生成乙酰CoA;3.2.2 乙酰辅酶A进入三羧酸循环;（1）乙酰辅酶A与草酰乙酸加水缩合成柠檬酸 （2）柠檬酸脱水生成顺乌头酸，然后加水生成异柠檬酸 （3）异柠檬酸氧化与脱羧生成α－酮戊二酸 （4）α－酮戊二酸氧化脱羧生成琥珀酰COA （5）琥珀酰COA生