1. 替加环素与其他抗生素的联合治疗：对体外实验，动物实验和病例报告的回顾性研究.pdfVIP

International Journal of Antimicrobial Agents 34 (2009) 8.e1–8.e9 Contents lists available at ScienceDirect International Journal of Antimicrobial Agents j o u rn al h omepage: h t t p: // www. elsevi /locate/ijantim icag Review Tigecycline in combination with other antimicrobials: a review of in vitro, animal and case report studies J.M. Entenza ∗ , P. Moreillon Department of Fundamental Microbiology, Faculty of Biology and Medicine, University of Lausanne, CH-1015 Lausanne, Switzerland a r t i c l e i n f o a b s t r a c t Keywords: Tigecycline has been investigated in combination with other antibacterials against a wide range of sus- Tigecycline ceptible and multiresistant Gram-positive and Gram-negative bacteria. Combinations have been analysed GAR-936 in vitro, in animal models and in human case reports. In vitro, tigecycline combined with other antimicro- In vitro combination bials produces primarily an indifferent response (neither synergy nor antagonism). Nevertheless, synergy In vivo combination occurred when tigecycline was combined with rifampicin against 64–100% of Enterococcus spp., Strep- tococcus pneumoniae, Enterobacter spp. and Brucella melitensis isolates. Combinations of tigecycline with amikacin also showed synergy for 40–100% of Enterobacter spp., Klebsiella pneumoniae, Proteus spp. and Stenotro