兰索拉唑三联疗法根除幽门螺杆菌的成本-效果分析.pdfVIP

·药物经讲学- 1至亲拉哇三联疗徐根除尚 ;J 螺杆菌的成本…效 果分析 陈 瑶\贺 薇(委底市中心医院药刺科，委底市 417000) 中阳分类号 R956 文献标识码 B 文章编号 1672 -2124(2010) 的 -0455 -02 摘 要 阔的:对 3 种兰索拉使三联疗法治疗.门螺杆篱感袋的方棠进行经济学伴价。方法:将 85 例经宵镜确诊为宵或十二指 肠溃扬伴 Hp f目性患者随机分为 3 组。 LCA 组，口民阿英雨林胶囊( A) 1. 0 g, bid ; LCF 组，口服吠喃甲鱼嗣片 (F)0.2 g, bid; LCZ 奴， 口服左氯氟沙 !L 胶囊 (Z)0.2 嚣， bid ，并且 3 组同时口..兰余拉嗖( L) 30 mg. bid ，克拉霉素颗拉剂 (C)5ωmg.híd ，疗程均为 7 日。 三联治疗结束后再分别予以兰索拉唆 30 mg. 桐，整个疗程为 3 周，采用药物经济学的成本唰效果法进行分析。结果 :3 级 Hp~~ 牟和 i贵扬愈合牟差异元显著蚀，但治疗成本不同。结论 :LCF 三串连疗法成本最低，并且效采最好。 关键词 主主索拉唆;幽门螺杆菌;成本效果分析;药物级济学 Lansoprazole 皿 included Triple Tberapy for Helicobacter Pylori Infection: Cost - effectiveness Analysis CHEN Yao. , HE Wei (Dept. of Pharmacy , Loudi Central Hospital , Loudi 417000 , China) ABSTRACT OBJECTIVE: To evaluate the cost 叩 effectiveness of three kinds of lansoprazole - included triple therapies in the treatment of Helicobacter pylori (Hp) infection. METHODS: 85 patients with stomach ulcer or duodenal ulc带 r confirmed gastroscopically associated with Hp - positive were randomly divided into 3 groups , i.队 LCA group received oral amoxicillin (A) 1. 0 g B. i. d; LCF group received oraI furazolidone tablets (F) 0.2 B. i. d , and LCZ group received orallevofloxacin capsules (Z) 0.2 Bid. Meanwhile , the patients in a11 three groups received oral lansoprazole (L) 30 mg B. i. d and clarithromycin granules (C) 500 mg B. i. d. After 3 - week treatment , cost 呻 effectiveness of the three schemes was analyzed. RESULTS: There was no significant difference in Hp eradication rate and ulcer healing rate among the 3 groups , but significant differences were noted acrOS8 the 3 grOUp8 in treatment costs. CONCLUSION: LCF - included triple therapy is of the lowest C08t yet best efficacy for Helicobacter pyl