-3,10 MMP in endometrial adenocarcinoma tissues.docVIP

 PAGE \* MERGEFORMAT 18 -3,10 MMP in endometrial adenocarcinoma tissues Of: Feng Jun, Gou Wen Li, Liu Dan, Li Xu [Abstract] Objective matrix metalloproteinase -3,10 (MMP-3, MMP-10) in endometrial adenocarcinoma expression, and infiltration with the disease, histologic grade, clinical stage, etc. relationship of MMP-3, MMP-10 in the incidence of endometrial cancer, invasion and metastasis and its significance. Methods Immunohistochemical methods were detected in 42 cases of endometrial carcinoma, 12 cases of atypical hyperplasia, 12 normal endometrial tissue MMP-3, MMP-10 expression, and analyzed statistically. Results of this experiment showed that endometrial cancer, endometrial atypical hyperplasia and normal endometrium MMP-3 expression rates were 73.8% (31/42), 25.0% (3 / 12), 8.3% (1 / 12), MMP-10 positive rates were 76.2% (32/42), 33.3% (4 / 12), 0% (0 / 12). MMP-3, MMP-10 expression showed a gradual downward trend, each statistical test showed that the two groups, MMP-3, MMP-10 in endometrial glands cancer and endometrial atypical hyperplasia, endometrial adenocarcinoma and normal endometrium organizations, were statistically significant (P lt;0.01),, MMP-3, MMP-10 expression and histological grade , myometrial invasion and clinical stage were related (P lt;0.01), MMP-3, MMP-10 in endometrial adenocarcinoma are significantly correlated (P lt;0.01), combined detection of MMP-3, MMP -10 can increase the detection rate of endometrial adenocarcinoma. Conclusion MMP-3 and MMP-10 can be used as endometrial adenocarcinoma and one of tumor markers, and the combined detection of MMP-3 and MMP-10 can enhance the uterus membrane the detection rate of adenocarcinoma. [Keywords:] endometrial adenocarcinoma, MMP -3, MMP -10 ChinaABSTRACT: Objective To explore the expression of matrix metalloproteinase-3 (MMP-3) and matrix metalloproteinase-10 (MMP-10) in normal endometrium, atypical hyperplasia and endometrial adenocarcinoma. We aimed to study the relation