3 - Daidzein Sulfonate on isolated heart ischemia-reperfusion injury in rats.docVIP

 PAGE \* MERGEFORMAT 8 3 - Daidzein Sulfonate on isolated heart ischemia-reperfusion injury in rats Author: Zhong Fu had Xiao-Liang Li Zhi-Hua Huang Ho Wei Zeng Jing [Abstract] Objective isolated heart perfusion model, the 3’-daidzein sulfonate on isolated heart after ischemia-reperfusion injury in rats. Methods The isolated rat myocardial ischemia-reperfusion injury model, in the perfusion fluid to enter the high and low doses of 3’-daidzein sulfonate (0.03, 0.01mg / L). Determination of coronary blood flow, heart rate, left ventricular systolic pressure, left ventricular diastolic blood pressure changes. Results 3’-daidzein sulfonate make the heart after ischemia-reperfusion increased irrigation flow rate, left ventricular systolic pressure increased, left ventricular diastolic blood pressure lower heart rate. Conclusion 3’-daidzein sulfonate coronary artery through the expansion, slowing heart rate and enhanced myocardial contractility of the isolated heart from ischemia-reperfusion injury protective effect. [Keywords:] 3’-daidzein sulfonate isolated heart ischemia-reperfusion injury 3’-daidzein sulfonate (3’-daidzein sulfonate sodium, DSS) is the main active ingredient of Chinese medicine puerarin daidzein for structural modification and the modification of newly synthesized strong water-soluble substances. 3’-daidzein sulfonate [C15H9O7SNa], structure shown in Figure 1, a white crystalline powder, from Shenyang Pharmaceutical University to provide teaching and research plant chemical purity of over 99%. The research group studies have shown that 3’-daidzein sulfonate with hypoxia [1], vasodilator [2], anti-arrhythmic effects [3] and the impact of isolated guinea pig right atrium and the contraction characteristics of self-discipline [ 4]. Our preliminary study also showed that 3’-daidzein sulfonate precursors of Daidzein on myocardial ischemia-reperfusion injury has a protective effect [5]. To explore the 3’-daidzein sulfonate whether it also has anti-