Adiponectin in patients with gout and insulin resistance and the relationship between atherosclerosis.docVIP

 PAGE \* MERGEFORMAT 9 Adiponectin in patients with gout and insulin resistance and the relationship between atherosclerosis Study: Chen Hui Zhou Yan Ouyang Yu Jian Zu Ying Qing Long Yan Sook Lin Feng [Abstract] Objective To study in gout patients with carotid artery intima media thickness (IMT and adiponectin, insulin resistance (IR relationship of adiponectin, IR in gout patients with atherosclerosis in the role. 60 cases were determined gout patients, 40 cases of uric acid in normal healthy volunteers (control group, fasting plasma glucose (FPG), fasting insulin (FINS), triglyceride (TG, total cholesterol (TC, high density lipoprotein (HDL C, low density lipoprotein ( LDL C, serum uric acid (Ua and adiponectin (APN levels, measuring carotid intima-media thickness IMT, while body mass index (BMI, insulin-resistance index (HOMA IR), and in the carotid IMT as dependent variable, FPG , FINS, lipids, BMI, HOMA IR, Ua, adiponectin as independent variables, the multiple stepwise regression analysis. Results gout group TC, LDL C, FINS, Ua, HOMA IR control group (P lt;0.05 or P lt; 0.01, and higher carotid IMT (P lt;0.05, while adiponectin levels were significantly lower than the control group (P lt;0.05. Multiple regression analysis showed that adiponectin, LDL C and BMI affect the arteries in patients with gout atherosclerosis and an independent risk factor. Conclusion of uric acid in patients with gout compared with the normal crowd obvious metabolic disorders and IR, and lower serum adiponectin levels, more prone to atherosclerosis. [Keywords:] gout, atherosclerosis, adiponectin, insulin resistance Gout patients with insulin resistance (IR), hyperuricemia is atherosclerosis (AS and independent risk factor for coronary heart disease, adiponectin and IR and AS are closely related, and gout adiponectin levels in patients with IR and AS The relations are not reported. This paper aims to determine the metabolic markers in patients with gout and adiponectin