Adjustable chip Shufeng Acute Toxicity Test.docVIP

 PAGE \* MERGEFORMAT 7 Adjustable chip Shufeng Acute Toxicity Test Author: An Feiyun, Liu Xinmin, Pan Xin-liang, XU Juan [Abstract] Objective To clarify the role of acute toxicity Shufeng rolling piece of the main component, as well as other components of the Strychnos acute toxicity effects. Methods containing Strychnos the Shufeng rolling film, simple and free Strychnos Strychnos rolling piece of Shufeng Kunming mice were exposed to gavage, using Bliss calculates the corresponding LD50. The results with Strychnos Shufeng rolling piece of the main acute toxicity manifested as convulsive tonic spasm, with symptoms of acute poisoning brucine similar. Containing Strychnos rolling piece of Shufeng LD50 of 1 253.5 mg / kg, the LD50 alone Strychnos for the 489 mg / kg, without Strychnos rolling piece of Shufeng LD50amp;gt; 9600 mg / kg. Conclusion strychni is Shufeng rolling piece of the main component of acute toxicity, Shufeng rolling piece of compound to reduce some of the other components can be Strychnos acute toxicity. [Keywords:] Shufeng rolling plate; Strychnos; acute toxicity; LD50 Abstract: ObjectiveTo clarify the main component of acute toxic effect in Shufeng Huoluo pills, and the effects of other components from Shufeng Huoluo pills on acute toxic effect of Semen Strychni.MethodsShufeng Huoluo pills (contain Semen Strychni), Semen Strychni and Shufeng Huoluo pills ( not contain Semen Strychni) were respectively given KM mices by gavage, Bliss method was used to calculate LD50.ResultsAcute toxic manifestations of Shufeng Huoluo pills (contain Semen Strychni) were twitch, entasia, which resemble acute toxic symptoms of Semen Strychni. LD50 for Shufeng Huoluo pills (contain Semen Strychni) and Semen Strychni were respectively 1253.5 mg / kg and 489 mg / kg, LD50 for Shufeng Huoluo pills (not contain Semen Strychni) was more than 9 600 mg / kg.ConclusionSemen Strychni was the main acute toxic component of Shufeng Huoluo pills, whereas acute toxic effect