Alprostadil Lipo-injection in elderly patients with lower extremity arterial disease of platelet activation.docVIP

 PAGE \* MERGEFORMAT 12 Alprostadil Lipo-injection in elderly patients with lower extremity arterial disease of platelet activation On: Sun Ning CAO Li Tian Jianli Chen Jun Feng Shuzhi [Abstract] Objective alprostadil injection lipo-vascular disease in elderly patients with lower extremity arterial function of platelet activation. Methods lower extremity arterial disease aged 120 patients were randomly divided into control group (60 cases and treatment group ( 60 cases. the control group given a daily injection of Ginkgo biloba extract 70 mg / d dissolved in 250 ml normal saline intravenously, continuous use of 14 d, the treatment group with alprostadil Lipo-injection 20 g / d dissolved in 20ml normal saline slow IV push, continuous treatment of 14 d, before and after treatment were observed in patients with symptoms, femoral artery, popliteal artery, posterior tibial artery, dorsalis pedis artery diameter and blood flow changes and blood glucose, blood lipids, liver enzymes, kidney function, platelet granule membrane glycoprotein 140 @, platelet CD62p and CD63, and prostacyclin and thromboxane. Results After treatment, elderly patients with lower extremity arterial disease symptoms improved femoral artery, popliteal artery, posterior tibial artery , dorsal artery diameter and blood flow volume has increased, platelet granule membrane glycoprotein @ 140, CD62p, CD63 and prostacyclin, thromboxane is known as a decline (P lt;0.05), no significant changes in other biochemical parameters (Pgt; 0.05 ). Conclusion alprostadil lipo injection can reduce elderly patients with lower extremity arterial disease platelet activation, improve their symptoms, safety for the treatment of elderly patients. [Keywords:] alprostadil injection lipo, the elderly, lower extremity arteries, platelet activation [Abstract] Objective To assess the infection of Liposomal prostaglandin E1 (Lipo PGE1) on hematoblastic activation function with lower limb arterial blood vessel dise