Amaranthus spinosus particle compound long-term toxicity studies.docVIP

 PAGE \* MERGEFORMAT 16 Amaranthus spinosus particle compound long-term toxicity studies 【Abstract】 Objective To study the particles of compound Amaranthus spinosus long-term toxicity, provide a reference for clinical safety of drugs. Methods according to the original herbs 58.0,29.0,14.5 g / kg, the rats were continuously fed with medicinal extracts of the original six weeks, and withdrawal observed 2 weeks, rats were observed during the administration of the general performance and toxicity. The results of 6-week administration and withdrawal observed during the two weeks no toxic reactions and delayed toxicity. Conclusion The materials to be used according to the clinical dose, means of treatment application is safe. Keywords: compound the long-term toxicity in rats Amaranthus spinosus particles The Long  term Toxicity Study of Fufang Cixian Granules on Rats DENG Jia  gang, WU Yu  qiang, ZHEN Zuo  wen, ZHOU Zhi 1. Pharmaceutical Factory of Guangxi Traditional Chinese Medical University, Nanning 530023, China; 2.Guangxi Institute for Drug Control, Nanning 530021, China Abstract: ObjectiveTo study the long-term toxicity of Fufang Cixian Granules on rats to provide some data for its clinical use. Methods80 rats were randomly divided into 4 groups, each group was given the extract of Fufang Cixian Granules intragastrically at doses of 0,58.0 , 29.0,14.5 g / kg for 6 weeks. The animals were observed for 2 weeks after medicine withdraw. Parameters were examined including general condition, bodyweight, blood cell, blood biochemistry, organ index, and histopathological exmination. ResultsNo toxic reaction was observed compared with control group. ConclusionFufang Cixian Granules should be safe in its clinical use with the recommended dosage. Keywords:: Fufang Cixian Granules; Rats; Long term toxicity Amaranthus spinosus compound particles independently of Guangxi College of Pharmaceutical R am