Bone morphogenetic protein in tibial osteotomy rapidly extended into the bone in the process of expression and significance of.docVIP

 PAGE \* MERGEFORMAT 16 Bone morphogenetic protein in tibial osteotomy rapidly extended into the bone in the process of expression and significance of Author: Fan-hua, Lin Yue-Qiu, Li main one, Zhou Zhongying [Keywords:] bone morphogenetic proteins Expression of bone morphogenetic protein and its significance during distraction osteogenesis following tibial osteotomy [Abstract] AIM: To study the expression of bone morphogenetic protein (BMP) and its significance during distraction osteogenesis. METHODS: Rabbits were used to make the models of tibial lengthening by osteotomy and distraction and sacrificed at 5, 10, 15, 20, 30 and 40 d after the interventions. BMP at the margins of bone formation in different time periods of tibial lengthening was detected immunohistochemically using monoclonal antibody against BMP. RESULTS: There was a persistent expression of BMP in the whole course of bone lengthening, but the position of BMP expression varied in different time periods. The expression of BMP can be found in most of the cells and tissues except inflammatory cells, osteoid and trabecular bone. There was a high level expression of BMP in mesenchymal cells, chondrocytes, osteoblasts, osteocytes and marrow cells. CONCLUSION: BMP plays an important role in the course of distraction osteogenesis. The deficiency of BMP may be a main reason for bone nonunion in distraction osteogenesis. [Keywords] bone morphogenetic proteins; osteogenesis, distraction; bone regeneration; bone nonunion [Abstract] Objective: To explore the process of fast-extending into the bone of bone morphogenetic protein (BMP) expression and its significance. Methods: The production of rabbit tibial osteotomy rapid extension of animal models, respectively, to extend the 5, 10, 15, 20, 30 and 40 derived in the extension area, to anti-bone morphogenetic protein monoclonal antibody (BMPMcAb) line SP immunohistochemical staining observed under light microscope. Results: In the whole process of