Concerned about the inflammatory bowel disease research cutting-edge information.docVIP

 PAGE \* MERGEFORMAT 9 Concerned about the inflammatory bowel disease research cutting-edge information [Keywords:] inflammatory bowel disease; research; Information Inflammatory bowel disease (inflammatory bowel disease, IBD) includes ulcerative colitis (ulcerative colitis, UC) and Crohn’s disease (Crohn’s disease, CD). A series of studies showed that although compared with Western nations, China’s incidence and prevalence was lag, but in recent years still on the rise. With regard to IBD research in the ascendant, the author of IBD pathogenesis, diagnosis and therapy of cutting-edge information to make a brief introduction. A study of the pathogenesis of cutting-edge information Research on the pathogenesis of IBD, mainly including the external environment, genetics, intestinal bacteria and immune mechanisms and so on. Genome in 2008 a study found that 21 are associated with IBD a new and significant sites, including interleukin 12 (IL  12) β , human chemokine receptor 6 (CCR6), the signal pathway JAK2, STAT3, LRRK2, CDKAL1, PTPN2/PTPN22, ICOSLG, ITLN1 other sites, which will help IBD-depth study of genetic susceptibility genes. On the other hand, in the pathogenesis of IBD immunology research process, from genome-wide association study found that CD and generated against cells of the adaptive immune response to pathogen-related susceptibility genes, including Mycobacterium tuberculosis infection in a further indication that the Deputy Mycobacterium tuberculosis and the CD’s relevance. Chen, Xiao and other scholars, recent clinical study found that flagellin-specific immune response activated intestinal mast cells, promoting immune inflammation of IBD. Janeczko and other U.S. scholars, the results of animal experiments revealed that intestinal mucosal flora composition and the density and composition of the intestinal inflammation and severity of manifestations was relevant. In addition, animal models and clinical data integration a study shows that th