Depression in patients with unstable angina undergoing elective PCI after clopidogrel Effects of drug response.docVIP

 PAGE \* MERGEFORMAT 13 Depression in patients with unstable angina undergoing elective PCI after clopidogrel Effects of drug response Of: ZHU Xin-Li Zhang Yong Ding Faming [Abstract] Objective To study the depression of unstable angina (USP) in patients with percutaneous coronary intervention (PCI) after clopidogrel drug response. METHODS 240 cases successfully in selected patients undergoing PCI were divided into depression group (117 cases) and non-depressed group (123 cases), PCI 2 h before surgery to give clopidogrel 600 mg Dayton clothing, after 75 mg / d to maintain. were within 1 d before surgery, after 1 d, 5 d and 1-month blood to turbidimetric method of platelet aggregation rate (PAG), flow cytometry platelet surface P selectin (CD62P) levels; compared two groups of patients were followed for 12 months and non-fatal major cardiovascular events The incidence of stroke. Results of preoperative PCI group than non-depressed group had a higher depression of platelet aggregation (q = 6.7613, P lt;0.01) and P selectin levels (q = 5.9827, P lt;0.01), and the degree of depression and linear relationship between platelet reactivity (r = 0.513, P lt;0.05). after 1 d, 5 d between the two groups, platelet aggregation rate (q = 7.9837, P lt;0.01; q = 6.8931, P lt;0.01) and P selectin levels were significantly (q = 11.8960, P lt;0.01; q = 7.4420, P lt;0.01), and the rate of clopidogrel resistance between the two groups was statistically significant (2 value of 6.853, P = 0.009; 2 value of 8.455, P = 0.004), sustained depression 1 month after clopidogrel resistance group rate is still higher (2 value of 4.861, P = 0.027). Conclusion The rate of depression increased platelet aggregation and platelet activation, influence clopidogrel in patients with drug reactions. [Keywords:] unstable angina pectoris; percutaneous coronary intervention; platelet aggregation; platelet P selectin; depression [Abstract] Objective To evaluate the significance of depres