Depression of testosterone levels in rats.docVIP

 PAGE \* MERGEFORMAT 11 Depression of testosterone levels in rats Of: Yang Limin Zhao Hua Kang Yuming Li Jing Ying Lan Tourism Bureau [Abstract] Objective To observe endogenous and exogenous rat model of depression within the testis and serum testosterone levels, androgen levels of depression. Methods Adult male rats given chronic mild stimulation of 21 d, prepared by outside sources rat model of depression (CMS group); to give the new born on the 8th day of the male rats were injected intraperitoneally freshly prepared chlorine microphone Paming (CLI) 40 mg / kg body weight, to 21 days, the preparation of endogenous depression rat model (CLI group). Results There was depression in the rat forced swimming test immobility time longer than the normal group (P lt;0.01), Upward time was significantly shorter than the normal group (P lt;0.01) ; open field test in the CMS group and the vertical level of the number of runs than the number of cells before stimulation significantly reduced (P lt;0.001); CLI rats running times on the level of the control group significantly increased compared with normal (P lt;0.05), rearing significantly reduced (P lt;0.01). CLI rat testis and serum testosterone levels testosterone levels were significantly higher than normal (P lt;0.05), while the CMS rats testis and serum testosterone levels testosterone level was significantly lower than normal (P lt;0.05). conclusion sex hormone secretion in rats with depression disorders, different types of depression testosterone levels in rats are inconsistent. unipolar depression decreased androgen levels in rats, bipolar depression, androgen levels in rats increased. [Keywords:] depression; testosterone; testis; rat [Abstract] Objective To investigate the changes of the level of testosterone in two types of depressed rats, and study the relationship between testosterone and depressive disorder. Methods The rats was exposed to chronic mild stress (CMS) such as food deprivation, water