Drug-induced liver disease 35 cases.docVIP

 PAGE \* MERGEFORMAT 7 Drug-induced liver disease 35 cases [Abstract] Objective: To analyze drug-induced liver disease, to increase vigilance and awareness of the disease and reduce the incidence of drug-induced diseases. Methods: Retrospective study of 35 cases 2003-2007 hospitalized cases of drug-induced liver disease, basis of recording disease and clinical features, liver function, treatment, prognosis, and to explore its possible mechanism. Results: The average age of drug-induced liver disease 48.2 years, mostly in 2 to 4 weeks after treatment with clinical symptoms, HBsAg-positive before treatment, drinking history compared to those HBsAg negative, no history of alcohol are more vulnerable to liver damage; medicine who caused concern, the group of 35 patients, 7 cases were caused by traditional Chinese medicine, accounting for 20.0%. Conclusion: Drug-induced liver disease multiple causes, the drug many, often misdiagnosed misdiagnosis, drug-induced liver disease caused by traditional Chinese medicine there is a growing trend in recent years, after disabling most of the drugs in patients with good prognosis, a few may die. [Keywords:] drug-induced liver disease; etiology; clinical characteristics Drug-induced liver disease is caused by the drug and its metabolites of liver damage [1]. Into the 21st century, applications for human drugs increasing, the number of exogenous chemicals in the liver under the action of enzymes into a water-soluble strong material, excreted by the kidneys, so the incidence of drug-induced liver disease also increased, because the disease’s clinical features and laboratory findings are nonspecific, easily misdiagnosed, to reduce the occurrence of the disease and improve the disease clinicians understanding, now admitted to our hospital from 2003-2007, 35 patients were diagnosed as cases of drug-induced liver disease were analyzed and summarized. 1 Clinical data 1.1 General Information The group of 35 patients were