Effects of puerarin on gallbladder motility in guinea pigs.docVIP

 PAGE \* MERGEFORMAT 7 Effects of puerarin on gallbladder motility in guinea pigs Authors: Qiu Hui, Zeng Jing, Xiao-Xin Li, Zhi-Hua Huang [Abstract] Objective To study of puerarin on the gallbladder motility. Methods of observation of guinea pig gallbladder muscle strips induced by acetylcholine antagonism of puerarin Gallbladder; antagonism of histamine caused by cholecystokinin movement; antagonism caused by high-K Gallbladder; antagonist Ca2 guinea pig gallbladder contraction caused by movements. The results of puerarin could significantly antagonize histamine, high K induced by cholecystokinin Sports and antagonism caused by accumulation of Ca2 movement of isolated guinea pig gallbladder. Conclusion puerarin could obviously antagonize the isolated guinea pig gallbladder. [Keywords:] puerarin cholecystokinin Puerarin (Puerarin) of the major components of the Department of Pueraria one of Pueraria only contained in the ‘Shen Nong’s Herbal Classic’. For legumes and kudzu Pueraria lobata root dry with fever Jie Ji, Sheng Jin Tou Zhen, Sun antidiarrheal effect. The main active ingredient is Pueraria puerarin and daidzein. Pharmacological effect of puerarin more clinical applications are very wide, for cardiovascular and cerebrovascular diseases, retinal diseases [1 ~ 6] and so has a good effect. The research group has been reported that puerarin in rabbit thoracic aortic strips of the effects of puerarin on isolated guinea pig right atrium and the contraction characteristics of self-regulatory effects of [7 ~ 8]. Now report its cholecystokinin movements. 1 Materials and Reagents Puerarin from Shenyang Pharmaceutical University, providing plant-based teaching and research (purity 97% and above). Paired with saline before the experiment the concentration required to reserve. Laboratory animals by Gannan Medical College of Laboratory Animal Center. 2 method [9 ~ 10] and results Take guinea pig gallbladder muscle strips, fixed with modified krebs solution wi