Effect of dexamethasone on airway inflammation in mice and STAT6 expression.docVIP

 PAGE \* MERGEFORMAT 14 Effect of dexamethasone on airway inflammation in mice and STAT6 expression [Abstract] Objective: To study the dexamethasone on acute asthma airway inflammation and its effects on signal transducer and activator of transcription 6 (STAT6) expression. Methods: Immunohistochemical detection given to Cyprus Betamethasone in the asthmatic lung tissue expression of STAT6. Results: bronchoalveolar lavage fluid from asthmatic mice (BALF) total cells, eosinophils (EOS) was significantly higher absolute value (P lt;0.01), the inflammatory cell count in the dexamethasone group than in the asthma group was significantly reduced (P lt;0.01). HE staining showed dexamethasone group were higher than the degree of airway inflammation in asthma group to reduce. STAT6 in airway epithelial cells, airway epithelium in asthmatic group STAT6 expression in cells than the control group increased STAT6 expression in the dexamethasone group compared with the asthma group was significantly less than the control group increased. STAT6 protein in bronchial epithelial cells and the absolute value of EOS in BALF were significantly correlated. Conclusion: Dexamethasone to some extent, reduce the asthma airway inflammation in mice, the mechanism may lower lung tissue by overexpression of STAT6, which depends on the STAT6/IL 4 pathway inhibition of acute airway inflammation. [Keywords:] bronchial asthma; signal transducer and activator of transcription 6; Th1/Th2; dexamethasone; mice Glucocorticoids in the treatment of asthma, first-line role has no doubt that it can inhibit the activation of many inflammatory cells and the generation and release of inflammatory cytokines, reduce vascular permeability, enhance 2 receptor sensitivity, for acute asthma chronic airway inflammation and remodeling has a positive effect [12]. In this study, through observation of the asthmatic airway inflammation and its signal transducer and activator of transcription 6 (STAT6) in ai