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EG-1 Her-2 p53 c-myc bcl-2 expression in breast cancer research
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EG-1 Her-2 p53 c-myc bcl-2 expression in breast cancer research
【Abstract】 The newly discovered gene EG-1 in breast cancer have a high expression with endothelial cells and epithelial cells of the proliferator-activated state-dependent. Her-2, p53, c-myc, bcl-2 in breast cancer research more, and its cellular signal transduction pathways have some understanding of the role. The full text of 5 genes profiles are reviewed.
Keywords: breast cancer oncogene tumor suppressor gene
Starting from the etiology of breast cancer, hoping to find the key to breast cancer. As the cellular and molecular biology research in recent decades in-depth, in particular the completion of the Human Genome Project, gene-chip technology, wide application of molecular pathogenesis of cancer has been an increasing number of scientists dedicated to research in this area revealed. Of breast cancer is no exception, have found a lot of work in the genesis and development of breast cancer or related proto-oncogenes and tumor suppressor gene, in this sum up the level of molecular biology of breast cancer mechanisms and related gene EG-1, Her-2 , p53, c-myc, bcl-2 in Research.
1 Introduction to molecular mechanisms of breast cancer
With the in-depth study of molecular biology, human life activity can be seen as intracellular signal transduction results. The expression of various cytokines, generation, activation, cell cycle, are all carried out through complex signal transduction system carried out. Pathways discovered so far there are many factors on these pathways are not isolated but intertwined to form the role of the complex signal network, and involved in cell cycle regulation and cell transformation mainly related to the MAPK pathway and PI-3K pathway, each pathway on the There are many factors play a positive or negative nature of their role, and interaction, linking with each other. Breast cancer research, the growth factor,
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