Erythromycin enteric-coated tablets to Release Study on Determination Method.docVIP

 PAGE \* MERGEFORMAT 21 Erythromycin enteric-coated tablets to Release Study on Determination Method 【Abstract】 Objective to erythromycin enteric-coated tablets release rate determination of three methods for systematic study and comparison, and to establish its optimal determination. Method of accounting for tons of hydrogen were used mouth alcohol chromogenic method, sulfuric acid color method, as well as high-performance liquid chromatography to erythromycin enteric-coated tablets release rate, for each method to the study methodology and validation. The results using three methods may accurately determine the manner of the release rate of erythromycin enteric-coated tablets, the results measured in different ways with little difference. Conclusion sulfuric acid color method for reagent easy to get, easy to operate, fast, accurate, as the best determination. Keywords: Dirithromycin Study on methods for the release determination of dirithromycin enteric ┐ coated tablets ABSTRACT Objective Three methods by which the release of dirithromycin enteric-coated tablets were determinated and compared. Methods Xanthydrol coloring method, sulfuric acid coloring method, and HPLC method were developed for determination of the release of dirithromycin enteric-coated tablets. Result All of these methods can be used to determine the samples precisely, and difference of the results among them is slightly. Conclusion Sulfuric acid coloring method is inexpensive, simple, rapid and precise, and it is regarded as the optimal method. KEY WORDS Dirithromycin; Enteric-coated tablets; Release Dirithromycin (dirithromycin) is a new type of second-generation macrolide antibiotic erythromycin from erythromycin ring amine and fatty acid aldehyde condensation formed. Dirithromycin peptides by blocking the process of transfer of bacteria, inhibiting bacterial protein synthesis. In vitro of erythromycin on the clinical evidence in a variety of com