Epalrestat type 2 diabetic nephropathy in early protective effect of.docVIP

 PAGE \* MERGEFORMAT 9 Epalrestat type 2 diabetic nephropathy in early protective effect of Study: Pine million Jihong Ou Yang Bo Xie Hongping [Abstract] Objective epalrestat early type 2 diabetic nephropathy urinary albumin excretion rate (UAE. Methods 36 patients with early diabetic nephropathy in type 2 patients treated on the basis of the original, I Epalrestat 150 mg qd treatment 16 months before and after treatment measured in patients with UAE, blood pressure, body mass index (BMI, serum creatinine clearance (Ccr, blood glucose, blood lipids. Results epalrestat before and after treatment in patients with blood glucose, blood lipids, blood pressure, BMI, Ccr did not change significantly (Pgt; 0.05, after treatment than before treatment UAE UAE decreased significantly (P lt;0. 01). Conclusions Inhibition of epalrestat to disease progression of early diabetic nephropathy. [Keywords:] Epalrestat UAE diabetic nephropathy Accelerated polyol pathway is an important pathogenesis of diabetic nephropathy: diacylglycerol (DAG re-synthesis increased, protein kinase C (PKC) activity increased, transforming growth factor 1 (TGF1 production increased, an increase of extracellular matrix [1]. aldose reductase inhibitor epalrestat, you can adjust the polyol pathway, it was reported that hyperfiltration in diabetic rats, reducing microalbuminuria in early diabetic nephropathy and the development of inhibition [2], urinary albumin excretion rate (UAE) is a diagnosis of proteinuria in type 2 diabetic nephropathy sensitive index, UAE is the increase in type 2 diabetic nephropathy increased the effective basis for the theoretical basis of the above, I observed epalrestat on early diabetic nephropathy, are reported as follows . 1 Materials and methods 1.1 study 36 cases of type 2 diabetic patients were followed up for our hospital or clinic patients are in line with the World Health Organization (WHO2 diagnostic criteria for diabetic nephropathy, and the