Erythropoietin on the retinal optic nerve protective effect of.docVIP

 PAGE \* MERGEFORMAT 10 Erythropoietin on the retinal optic nerve protective effect of Abstract erythropoietin (Erythropoietin, EPO) a major role in the bone marrow megakaryocyte precursor cells to stimulate erythroid progenitor for the early erythroblast colony formation of mature red blood cells. In recent years, a large number of studies have shown that EPO and EPO receptors in the nervous system on functional expression in vitro and animal experiments have shown significant neurological protection. In ophthalmology, glaucoma, retinal detachment, retinitis pigmentosa and other diseases common pathological mechanism of retinal ganglion cells, photoreceptor cells and other neuronal apoptosis, eventually leading to loss of vision. Thus, EPO’s neuroprotective effect of the treatment of these diseases have some practical significance. EPO is now summed up the nature of the molecular mechanism of neural protection and signal transduction pathway to explore the EPO for the treatment of glaucoma, the optic nerve to protect the foundation and possibilities. Keywords: Erythropoietin neuroprotection apoptosis signal transduction of retinal ganglion cells in glaucoma 1 EPO’s biological functions EPO (erythropoietin, EPO) is the molecular weight of about 30 ~ 39ku glycoprotein previously that it is mainly the generation of red blood cells regulate hematopoietic cytokines, resulting in the fetal liver and adult kidney. EPO and its receptor (erythropoietin receptor, EPOR) mainly in bone marrow hematopoietic stem cells and stimulate it to red blood cell differentiation. EPO’s main function is to inhibit hematopoietic erythroid precursor cells apoptosis and promote it to the proliferation and differentiation of red blood cells [1]. Erythropoietin can further improve an organization’s oxygen supply, the same time, tissue oxygen supply and as a key hormone feedback mechanism is the generation and hematopoietic function of EPO main regulator.