Esophageal squamous cell carcinoma of PINCH protein expression and significance of.docVIP

 PAGE \* MERGEFORMAT 19 Esophageal squamous cell carcinoma of PINCH protein expression and significance of Author: Zhu Zhenlong, Yang Yanhong, Zhang Yu, Wang Min, Cui Dong-sheng, Chang Jung-Ming-Wei Wang, Xiao-Feng Sun, Ann Rearden 【Abstract】 Objective To investigate the PINCH protein in esophageal squamous cell carcinoma and its clinicopathological significance. Methods The immunohistochemical ABC method detected 10 cases of normal esophageal mucosa and 64 cases of esophageal squamous cell carcinoma of PINCH protein expression, and to analyze its clinical significance. The results of PINCH protein in squamous cell carcinoma was related to the interstitial heterogeneity of expression, the positive rate was 56.25% (36/64), significantly higher than the normal esophageal mucosa (0 / 10) (P lt;0.05), significantly higher , but also in the tumor-infiltrating edge of the positive more pronounced. PINCH protein expression and patient sex, age and histological grade squamous cell carcinoma was no correlation; lymph node metastasis of squamous cell carcinoma PINCH protein expression rate of 90% (18/20), no metastasis positive rate of squamous cell carcinoma cases, 40.91% (18/44), both significantly different when compared (P lt;0.05). Conclusion PINCH protein expression in esophageal squamous cell abnormalities may be conducive to tumor invasion and metastasis. Tip PINCH protein can be used for a tumor-associated stroma markers to predict tumor invasion and lymph node metastasis ability. On the prognosis of the tumor has an important significance, and may be associated with the tumor stroma, a new anti-cancer treatment target. 【Key Words】 PINCH protein; squamous cell carcinoma; esophagus; immunohistochemistry Expression and Significance of PINCH Protein in Esophagus Squamous Cell Carcinoma Keywords:: PINCH protein; Squamous cell carcinoma; Esophagus; Immunohistochemistry In signal transduction, the adapter protein domain by protein