Esophageal tissue and margin P53 protein expression with prognosis.docVIP

 PAGE \* MERGEFORMAT 8 Esophageal tissue and margin P53 protein expression with prognosis Study: Tak Chi Cheng, Jiang Cheng list, Zhanghu Xiang, He Zhifeng, Chi Chuang [Abstract] Objective: To detect esophageal squamous cell carcinoma and the cutting edge of the P53 protein, and analyze its relationship with prognosis. Methods: Immunohistochemistry was used to detect cancer and the cutting edge of the P53 protein expression and analysis of the expression of negative and the survival rate between positive. Results: Cancer patients with positive P53 5-year survival rate was 25.0%, negative 43.8%. cutting edge of P53-positive patients survival rate was 11.1%, negative 39.2%. Conclusion: Esophageal squamous cell carcinoma with P53 protein expression in surgical margins may affect the prognosis. [Keywords:] esophageal squamous cell carcinoma of the prognosis of surgical margin P53 Cutting edge of postoperative local recurrence of cancer is the source of the tumor, the rate was 4.2% ~ 31.3% [1], seriously affecting the prognosis of patients. The traditional method for clean surgery to determine whether the peripheral tissues is based on the cell morphology Observation of this method cancer cells and normal cells based on morphological differences, but on the existence of potential changes within cells is unknown. P53 gene is found in human tumors so far the most relevant genes, P53 protein is a product of P53 gene mutation is a factor promoting tumor growth in 30% to 50% of esophageal cancer, there is P53 gene mutation [2]. We examined 60 cases of esophageal squamous cell carcinoma of P53 protein with cutting edge expression, and to analyze the effect on prognosis. 1 Materials and methods 1.1 General Information January 2002 -2003 in our department on June 60 of esophageal cancer surgery patients, including 43 males and 17 females, aged 32 to 75 years (mean 56.3 + -14.6 years. Case inclusion criteria : Preoperative pathology were squamous cell carci