FAK in the tissue injury in the research and its significance in forensic medicine.docVIP

 PAGE \* MERGEFORMAT 11 FAK in the tissue injury in the research and its significance in forensic medicine Author: Zhang Xin, Zhang Shuguang, Song GeneralTouch, Zhang Ri-hui, ZHOU Mei [Abstract] inside the cell, when the focal adhesion kinase (focal adhesion kinase, FAK) by extracellular stimulation, which is activated while the occurrence phosphorylation, phosphorylation of FAK activation downstream of the factors to change cell behavior. FAK is an important inside the cell signal transduction molecules, which in the signal transduction from surface receptors to the nucleus plays a key role in the process. This, FAK and cellular interactions within a variety of molecules, thus involved in the regulation of a variety of cell functions, such as cell proliferation, migration, cell proliferation, apoptosis and cell survival, in forensic science will also have to study the importance of FAK significance. [Keywords:] Forensic Pathology; focal adhesion kinase; injury; time estimation FAK (focal adhesion kinase, FAK) non-receptor protein tyrosine kinase (protein tyrosine kinase, PTK) one, mainly in the cytoplasm, the play-mediated cell adhesion, migration, survival and cell cycle regulation such an important role. FAK and other signal transduction pathways and their mechanism of interaction between the role of apoptosis is characterized by recent research hotspot in the tissue injury FAK In this paper, the research progress and significance in forensic medicine. The biological characteristics of 1 FAK 1.1 FAK structure of FAK, also known as pp125FAK, 1992 by Hank and so on from the v-src-transfected chicken embryo fibroblast cells, cloned identified out due to close relationship with the cell adhesion, so named focal adhesion kinase (FAK). Pyk2 (Protein-rich tyrosine kinase 2) is a non-receptor proline-rich tyrosine kinase 2, also known as cell adhesion kinase β (CAKβ ); related focal adhesion tyrosine kinase (RAFTK); Ca2-dependent tyrosine kinase (CADTK) or fo