First episode major depression patients with bilateral frontal lobe and hippocampus of proton magnetic resonance spectroscopic imaging.docVIP

 PAGE \* MERGEFORMAT 13 First episode major depression patients with bilateral frontal lobe and hippocampus of proton magnetic resonance spectroscopic imaging Of: Ma is warehouse, SUN Yan, high into the Court, pro-Sun Lee, Ding Hui, fish Brahma [ABSTRACT] Objective proton magnetic resonance spectroscopy (1H-MRS) of first episode major depression in patients with changes in brain nerve biochemical substances. Methods case group and control group 23 patients. 1H-MRS measurements using two sets of bilateral frontal cortex and hippocampus N-acetyl aspartate (NAA), glutamate complex (Glx), choline (Cho), creatine (Cr), and inositol (mI) levels, calculated NAA / Cr, Glx / Cr, Cho / Cr, mI / Cr. the results of case group left frontal NAA / Cr, the right frontal lobe Glx / Cr, NAA / Cr and left hippocampal Glx / Cr, NAA / Cr lower than the control group, the right frontal lobe and hippocampus mI / Cr higher than in the control group. Conclusion major depression may be related to the pathogenesis of neurological disorders, glutamate system and the second messenger system abnormalities. [Keywords:] first episode major depression, proton MR spectroscopy, frontal cortex and hippocampus ABSTRACT: Objective To measure metabolism in brain of first episode major depression patients with 1H-MRS. Methods Single-voxel proton magnetic resonance spectroscopic (1H-MRS) examination of bilateralis frontal lobe and hippocampus was conducted in 23 patients with first episode major depression and 23 age-, sex-and education-matched healthy controls. We examined the metabolism such as NAA, Cho, Cr, Glx and mI in bilaterlis frontal lobe and hippocampus of patients. Results Bilateralis frontal lobe NAA / Cr, right frontal lobe Glx / Cr and left hippocampus NAA / Cr and Glx / Cr were significantly lower in MD patients versus controls, but right frontal lobe and right hippocampus mI / Cr significantly higher than in controls. Conclusion Nerve cell activity disorder, abnormal second