Four cases before and after intravenous infusion of cefoperazone sodium and alcohol-induced disulfiram-like reaction of Nursing.docVIP

 PAGE \* MERGEFORMAT 5 Four cases before and after intravenous infusion of cefoperazone sodium and alcohol-induced disulfiram-like reaction of Nursing Disulfiram-like reaction is a drug-induced acute, also known as disulfiram-like, or disulfiram-like reaction [1]. Disulfiram is a drug, the body does not produce its own effect, but after taking the drug alcohol, its inhibition of aldehyde dehydrogenase in the liver, leading to an intermediate metabolite of alcohol metabolism of acetaldehyde blocked, so that the blood increasing the concentration of the reaction of acetaldehyde [2]. Cephalosporins also inhibit aldehyde dehydrogenase, which led to a similar response to the above, clinically referred to as the disulfiram-like reaction. February 2007 ~ October 2008 in our hospital were treated four cases of alcohol before and after intravenous infusion of cefoperazone sodium Disulfiram-like reaction in patients, after a timely rescue and care, were discharged Nursing now reported as follows. A clinical data 1.1 General Information 4 patients in this group were male, aged 19-37 years, mean 28 years. Of which 1 case was drinking the night before infusion reaction induced by infusion during the remaining 3 cases, after 30min-3h infusion of alcohol. 1 case drink beer 500ml, 3 Li drinking white wine 50 ~ 200ml. 1.2 Clinical manifestations facial flushing, conjunctival hyperemia, blurred vision, head and neck vessels severe pulsating or pulsatile headache, dizziness, nausea, vomiting, limb weakness, sweating, dry mouth, chest pain, chest tightness, shortness of breath, lips cyanosis, difficulty in breathing and so on. Palpation decreased blood pressure, heart rate acceleration (114-126 times / min), ECG changes in normal or in part (ST segment depression). Progress in these two cases to the low blood pressure status, blood pressure dropped to 50-70/20-40mmHg, 1 cases with loss of consciousness. 2 Care 2.1 The patient was supine immediately so that shock to take ‘V’