Freckle on the beauty particles caused by anti-D-galactose the role of skin aging in mice_0.docVIP

 PAGE \* MERGEFORMAT 10 Freckle on the beauty particles caused by anti-D-galactose the role of skin aging in mice [Abstract]: Objective To study the oral administration of anti-aging skin beauty freckle grain effect and mechanism. Methods Kunming female mice daily subcutaneous injection of D-galactose 1 000 mg / (kg · d) aging model in mice, while at high, medium and low dose (6.68,3.34,1.67 g / kg) were fed with beauty freckle grain, 42 d after the mice were measured in the back skin tissue glutathione peroxidase (GSH-Px) activity and serum estradiol (E2) levels, and study of mouse uterus, ovary, skin, dry weight, wet weight and water intake. The results with the aging model group, treatment group beauty freckle grain mouse skin in the GSH-Px activity and E2 was significantly increased, especially in the dose of the best (P lt;0.05, P lt;0.01), while the mouse uterus, ovary, skin, dry weight, wet weight and water intake an increasing trend. Conclusion beauty freckle particles on D-galactose induced aging mouse skin anti-aging effects significantly. [Keywords:] beauty skin freckle grain D-galactose aging mice Abstract: Objective To investigate the mechanism of anti-aging effect of Yangyan Quban particles on the aging skin. Methods With the dose of D-galactose 1 000 mg / (kg · d) by sc administration to the female mice for 42 days, the aging model was established. The mice received Yangyan Quban particles (6.68, 3.34, 1.67 g / kg) by ig administration at the same time of injecting D-galactose. Forty-two days later, the dorsal skin samples were collected to determine glutathione peroxidase (GSH-Px) activity and serum estradiol (E2) contents, and the influence on uterus, ovary, skin dry and wet weight and the amount of water intake were studied. Results Compared with the aged model mice, the GSH-Px activity and E2 contents in the mice treated with Yangyan Quban particles were increased remarkably, especially the medium is the best dose (P lt;0.05, P lt;0.