Heart failure in patients with TNFα IL6 IL10 levels and cardiac function in the relationship between the.docVIP

 PAGE \* MERGEFORMAT 3 Heart failure in patients with TNFα IL6 IL10 levels and cardiac function in the relationship between the Keywords:] Left ventricular dysfunction, congestive heart failure strength of tumor necrosis factor  α interleukin  6 interleukin  10 Some scholars have pointed heart failure (CHF) incidence of the ‘cytokine hypothesis’, that the regulation of cytokine network between the CHF for the occurrence and development plays an important role; inflammatory cytokines such as tumor necrosis factor (TNF  α ), leukocyte interleukin  6 (IL  6) etc. and anti-inflammatory cytokines such as interleukin  10 (IL  10) interaction such as the formation of positive and negative feedback loop, the two often are in balance / imbalance between the change in the unity of opposites to regulate the left ventricular remodeling, affecting the prognosis of CHF patients [1]. To explore the cytokine levels in patients with CHF and its relationship with cardiac function in the relationship between the state, the author examined 71 cases of CHF in patients with plasma TNF  α , IL  6, IL  10 level, and with left ventricular ejection fraction (LVEF ), left ventricular end-diastolic diameter (LVEDD), left ventricular end systolic diameter (LVESD), cardiothoracic ratio (HTR) were compared. An object and method 1.1 Object Selection in January 2004 ~ December 2005 hospitalized CHF patients with 71 patients (CHF group), male 45 cases, female 26 cases, age (58.3 ± 8.3) years (42 ~ 78 years); in which dilated cardiomyopathy 26 cases, 17 cases of rheumatic heart disease, ischemic cardiomyopathy in 28 cases. According to the literature [2] cardiac function classification standards are divided into three groups: 18 cases of cardiac function grade Ⅱ , Ⅲ grade 33 cases, Ⅳ grade 20 cases. Select the same period in healthy volunteers, 50 cases of physical examination for the control group, 31 males and 19 females, age (53.6 ± 9.2) years (36 ~ 72 years).