Hematopoietic stem cell transplantation for treatment of lower limb ischemic disease research.docVIP

 PAGE \* MERGEFORMAT 18 Hematopoietic stem cell transplantation for treatment of lower limb ischemic disease research Keywords: lower limb ischemia Severe lower limb ischemia is a common debilitating clinical disease with high incidence, high morbidity and high mortality rates of serious impact on people’s quality of life and even life-threatening. Rest pain, skin ulcers or gangrene is a typical clinical manifestations. Although the current study of angiogenesis in the lower extremities has some technical progress, but there are still some cases in addition to have no choice but amputation. Because of this, people have increased angiogenesis in the treatment of severe lower extremity ischemia has a strong interest. Angiogenesis has become a kind of treatment of ischemic disease, new methods [1]. In recent years, along with a variety of biological characteristics of adult stem cells, the continuous deepening of awareness and separation and purification of these stem cells, the continuous improvement of the means to make use of cell therapy such as therapeutic angiogenesis in the infarct area approach to re-establish an effective collateral circulation has become possible [2]. A basic theory Stem cells are self-renewing capacity of highly differentiated cell populations can be produced through cell division phenotype and genotype identical daughter cells to maintain the size of their cell populations, while differentiation can be further generate at least one type of highly differentiated daughter cells. Stem cells are self-replicating, or differentiate into functional cells, mainly due to the state’s own cells and micro-environmental factors made a decision. The state of their own stem cells, including cell cycle regulation of various cyclins and cyclin-dependent kinase, gene transcription factor, affecting the cytoplasmic factors of asymmetric cell division. Micro-environmental factors, including stem cells and surrounding cells, stem c