High Performance Liquid Chromatography Keteling Dispersible Tablets Chlorpheniramine Maleate in the content of.docVIP

 PAGE \* MERGEFORMAT 13 High Performance Liquid Chromatography Keteling Dispersible Tablets Chlorpheniramine Maleate in the content of 【Abstract】 Objective To establish Keteling Dispersible Tablets Chlorpheniramine Maleate method for the determination. Methods HPLC Determination of Chlorpheniramine Maleate the content column for the Nucleodur C18 Gravity (250 mm × 4.6 mm, 5 μm); mobile phase of acetonitrile  water (containing 0.3% glacial acetic acid, 0.1% triethylamine) (27:73); flow rate of 1.0 ml / min; detection wavelength 262 nm. The results of chlorpheniramine maleate in the range of 0.0302 ~ 0.906μg showed good linear relationship within, r = 0.9999; The average recovery was 99.5%, RSD = 1.5%. Conclusion This method can be accurately carried out quantitative detection Keteling dispersible tablets can be used for the preparation of quality control. Keywords: Keteling Chlorpheniramine maleate tablet by high performance liquid chromatography Abstract: ObjectiveTo establish a method for the determination of chlorphenamine maleate in Keteling Dispersible Tablet by HPLC. MethodsHPLC was performed on Nucleodur C18 Gravity (250 mm × 4.6 mm, 5μm). The mobile phase was acetonitril-water (0.3% acetic acid, 0.1 % triethylamine) (27:73). The detection wavelength was 262 nm and flow rate was 1.0 ml / min.ResultsChlorphenamine maleate showed a good linearity in the range of 0.0302 ~ 0.906μg, r = 0.9999.The average recovery was 99.5%, and RSD was 1.5%. ConclusionThis method is effective and can be used for the quality control of chlorphenamine maleate in Keteling Dispersible Tablet. Keywords:: Keteling Dispersible Tablet; Chlorphenamine maleate; HPLC Keteling dispersible dry extract from Ficus microcarpa, and chlorpheniramine maleate in the composition, has antitussive, expectorant, anti-asthma, anti-inflammatory role. Used in the treatment of cough and asthma and chronic bronchitis. In order to better control product quality, our