HMGCoA reductase inhibitor atorvastatin on the kidney of diabetic rats and its mechanism of protection.docVIP

 PAGE \* MERGEFORMAT 17 HMGCoA reductase inhibitor atorvastatin on the kidney of diabetic rats and its mechanism of protection Of: Zhaoxi Li, Wei-Wei, Jiang Guoping, Liu Xiaolan, Ji Fang [Abstract] Objective HMG CoA reductase inhibitor of atorvastatin on renal protective effect in diabetic rats and its possible mechanism. Methods of streptozotocin (STZ) intraperitoneal injection of a rat with diabetes (DM) model successfully were randomly divided into model control group and atorvastatin group, a separate control group, 8 rats in each group. 1,2,4,8 in the first week after the rats were measured 24h urinary albumin (UAL), blood urea nitrogen (UN) and creatinine (Cr) levels. the first 8 weeks, renal tissue and peripheral blood taken. by Western blot, protein in rat kidney tissue expression of Smad2; Immunohistochemistry Detection of renal tissue expression of TGF 1; radioimmunoassay of serum laminin (LN) expression. Results from the 1st week, compared with the normal control group, model control group and atorvastatin therapy rats 24h UAL, UN and Cr levels were significantly higher (P lt;0.01); and from the 4th week, compared with the control group, atorvastatin treatment group, 24h UAL, UN, Cr was significantly lower (P lt;0.01). and the normal control group, model control group in the renal tissue despite increased levels of Smad2 protein, but no significant difference (Pgt; 0.05); and compared with the control group, atorvastatin treatment group Smad2 protein expression was significantly lower (P lt;0.01). and the normal control group, model control group, renal tissue expression of TGF 1 significantly increased; and compared with the control group, atorvastatin treatment group, positive cells in TGF 1 significantly reduced in volume. model group serum LN levels significantly higher than the normal control group (P lt;0.01); the atorvastatin treatment group compared with model LN expression was significantly decreased (P lt;0.05). Conclusion HMG CoA red