Hypoglycemic side kidney type 2 diabetic MKR mice protective effect of early.docVIP

 PAGE \* MERGEFORMAT 15 Hypoglycemic side kidney type 2 diabetic MKR mice protective effect of early Of: Aibi Chen, Xiao Man Jiang, Yu Rong, into fine China, Mingxia, Wu Rong participation, Chen Yu, Zhang Yan [Abstract] Objective To investigate the Yin Qi, kidney and blood detoxification method group party (hypoglycemic kidney side) of the MKR transgenic mice with type 2 diabetic nephropathy in rats. Methods 15 MKR mice 24 weeks old, according to gender and fasting blood glucose stratified, randomized into 3 groups, namely, model group, group [hypoglycemic kidney side 16.72 g / (kg · d)], western medicine group [gliquidone 4.33 mg / (kg · d) + beta enalapril 1.44 mg / (kg · d)], over the same period a separate C57BL / 6 wild-type mice were normal. medication group were given the same dose of drug orally, the model group and normal group received distilled water .30 d later, mice were observed simultaneously fasting blood glucose, urinary albumin and urinary β2-microglobulin (ELISA) levels, electron microscopy of renal pathology. Results After 30 d administration, hypoglycemic kidney can only MKR mice was significantly reduced fasting blood glucose, urinary albumin and urinary β2-microglobulin excretion, compared with before administration, P lt;0.01, compared with model group, P lt;0.01. electron microscopy results showed: blood glucose side group of kidney reduce the glomerular basement membrane thickening, mesangial matrix accumulation decreased. Conclusion hypoglycemic kidney can only MKR mice significantly improved fasting blood glucose, reduce urinary albumin and urinary β2-microglobulin levels, improve renal pathological damage , thus delaying the MKR mice further development of kidney disease. [Keywords:] MKR transgenic mice, diabetic nephropathy, kidney side hypoglycemic Protective Effect of Jiangtangyishen Decoction on Early-stage Diabetic Nephropathy of MKR Mice AI Bi-chen, XIAO Man-jiang, YU Rong, et al (School of Basic Medical Scie