In breast cancer tissue hypoxia-inducible factor1α expression in.docVIP

 PAGE \* MERGEFORMAT 2 In breast cancer tissue hypoxia-inducible factor1α expression in Author: Geng Wang, Hao Lamson, Tan most, YI Jian-Hua, Hui-Zhen, Wang Minghua, Sun Qin [Abstract] Objective To investigate the breast cancer tissue hypoxia-inducible factor  1α (hypoxia  inducible factor 1 alpha, HIF  1α ) expression and proliferating cell nuclear antigen (proliferating cell nuclear antigen, PCNA) and clinical pathological factors. Methods using immunohistochemical SP method detected breast fibroadenoma, normal breast hyperplasia and breast cancer in HIF  1α , PCNA protein expression. Results HIF  1α protein in breast fibroadenoma, normal breast tissue did not express hyperplasia; ductal carcinoma in situ positive rate of 55% (11/20), invasive breast cancer in 85% (51/60); HIF  1α in lymph nodes, estrogen receptor status and histological grade were significantly different expression. PCNA positive rate of breast cancer in 75% (60/80), in which carcinoma in situ was 65% (13/20), invasive carcinoma was 78.3% (47/60). In breast cancer HIF  1α expression and PCNA significantly correlated (r = 0.693, P